New Publication: The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits

ADAC and Emes Lab researchers Tom Giles and Richard Emes conducted transcriptome analysis of host after infection with wild type and A2 negative alcelaphine herpesvirus-1. Accepted article at Virus Research 2014

Highlights

  • The A2 gene product of alcelaphine herpesvirus-1 is a basic leucine zipper protein.
  • Deletion of the A2 gene in the virus genome delays virus growth in culture and also the onset of malignant catarrhal fever in rabbits.
  • The A2 gene product is involved in pathways affecting host T cell receptor phenotype, signalling, cell cycle and apoptosis.
  • The A2 gene product is involved in regulating host T cell cytotoxicity. This is important as T cell cytotoxicity is thought to be responsible for disease induction in MCF.
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