ADAC and Emes Lab researchers Tom Giles and Richard Emes conducted transcriptome analysis of host after infection with wild type and A2 negative alcelaphine herpesvirus-1. Accepted article at Virus Research 2014
- The A2 gene product of alcelaphine herpesvirus-1 is a basic leucine zipper protein.
- Deletion of the A2 gene in the virus genome delays virus growth in culture and also the onset of malignant catarrhal fever in rabbits.
- The A2 gene product is involved in pathways affecting host T cell receptor phenotype, signalling, cell cycle and apoptosis.
- The A2 gene product is involved in regulating host T cell cytotoxicity. This is important as T cell cytotoxicity is thought to be responsible for disease induction in MCF.