Moreton J, Malla S, Aboobaker AA, Tarlinton RE, Emes RD. (2014) Characterisation of the horse transcriptome from immunologically active tissues.
PeerJ 2:e382 http://dx.doi.org/10.7717/peerj.382
The immune system of the horse has not been well studied, despite the fact that
the horse displays several features such as sensitivity to bacterial lipopolysaccharide
that make themin many ways a more suitable model of some human disorders than
the current rodent models. The difficulty of working with large animal models has
however limited characterisation of gene expression in the horse immune system
with current annotations for the equine genome restricted to predictions fromother
mammals and the few described horse proteins. This paper outlines sequencing of
184 million transcriptome short reads from immunologically active tissues of three
horses including the genome reference “Twilight”. In a comparison with the Ensembl
horse genome annotation, we found 8,763 potentially novel isoforms.